Randomize section of material

So I am working on a city scene that will be seen during both daylight and night-time. It is a simplistic setup for most buildings with a single window tiled across most of the building’s mesh. If you look below you’ll see an example of one of the tile’s diffuse texture next to an alpha.

What I’m looking to do is for the night-time scene somehow randomize the hue/ saturation/ emissive properties of the ‘window’ section (the white part in the alpha) to create something similar to the example below which, in this case, would be using the same diffuse for the 2x2. I know about material instancing but the randomization only seems to work per static mesh and not within the same mesh or per ‘tile’.

31708-alpha_dif.jpg