I’m not sure what exactly you mean, so I’m going to make the assumption that want to get rid of the orange wires from within your Blueprint.
If you look at the top right of the graph it says ‘Read Only’ and that is because you’re playing the editor and therefore can only view the Blueprint and not edit it. So, if you stop playing the Blueprint will become editable again. Like I said, I’m not sure what you’re asking, so please correct me if I’ve provided you with the incorrect answer.
You can’t make new wires if you are playing, thats why all wires are orange, because they are simulating how the “flow” goes through the nodes. Stop your game and makes the changes then.