What are the limitations of "Tick Even When Paused?"

The tooltip for the Tick Even When Paused flag on Blueprint classes reads (emphasis mine):

Bool indicating that this function should execute even if the game is paused. Pause ticks are very limited in capabilities.

I have experimented with this flag on several Blueprint classes and observed no change on any of them while the game is paused. Can someone explain to me what these limitations are and what this flag might be used for?