Level Streaming for Large Open World

Looking to be pointed in the right direction for level streaming for my 16km x 16km (Tiled landscape) world.

Also am I always supposed to load all the tiles every time I open the project?

I cannot find something that shows in an open world settings always with a door opening.
Also is there something you have to do to be able to paint foliage on the tiled landscapes?
The landscape proxies and whatnot are always greyed out so I cannot paint on them.

Have you found anything useful about it? I mean, how to make level streaming for large open-world levels? (for closed rooms it’s pretty easy, but how to do it for open landscapes…)