Isometric and 2D assets

Is it possible to make something like a Kairosoft game using a camera in orthographic mode and 2D assets?

Thank you.

It’s possible, but you need isometric camera instead.
Also from my point view UE4 is overpowered for 2D applications.

Yeah, thank you for your necroanswer. Anyway, 2 years later I can say it is possible but it isn’t advisable. ^^

Had similar question, if it’s worth for 2D, or it’s better to try other engine.
Finally changed my idea to simplified 3D =)