4.18.2 Material updates does not save

Hi,
just updated to 4.18.2 from 4.18.1. Everything works fine, when import a scene. Then i save the file, after all materials updates. There are about 30.000 materials. Then i save the work and when i start the editor again, it is updating the materials again and it will take another 15min for 30.000 materials. If i want to render out a sequence, the same problem, because the material is not saved, the whole sequence looks different than in the editor, like skylight is not showing up and everything is dark.
4.18.1. everything was fine, now with 4.18.2. the save function is not working after updating the materials.