Are there any issues using sequencer for gameplay

Sequencer is intended for cinematics. However, it does not require you to disable player input to play a sequence. If you wanted to, say, move a platform, making a moving sequence for the object would be easier than using a timeline and a vector lerp node to move the platform. Is this ok to do, or is it against best practices?

That’s perfectly fine, In fact I believe its the norm for moving things like platforms, opening doors, moving trains in the bkg, probably even trains the player can ride in.