Won't even let me open a tab

I have big problem where I wouldn’t do anything at all without. I am using UE 4.12.5, and it will now let me open certain tabs. I cant open File or Edit. I cant even click on Add New on “Content browser” I can click on the tabs but it wont open. This is extremely difficult and annoying. help me.

4.12? Do consider upgrading. If you cannot, for some reason, try resetting the window layout.