How to Fill a Box with Mesh Particles in Niagara FX System and How to make them interact with other actors in the Level?

Hi, Can someone help or guide me for “How to Fill a Box with Mesh Particles in Niagara FX System and How to make them interact with other actors in the Level?”. Is it possible to add these Niagara particles to level sequencer to play them at a certain frame. Please help me. Thanks in advance.